GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2108622 | 1 | rs55744319 | chr19:15981821 | CYP4F11 | chr19:16023180-16045676:- | -0.24 | -3.71 | 0.000229 | Acenocoumarol maintenance dosage;Vitamin E levels;Circulating phylloquinone levels;Metabolite levels;Response to Vitamin E supplementation;Warfarin maintenance dose |
| THCA | cis | rs6978712 | 1 | rs55748686 | chr7:127148595 | GRM8 | chr7:126078652-126893147:- | -0.35 | -3.57 | 0.000398 | Medication adherence in chronic diseases |
| THCA | cis | rs9217 | 1 | rs55749333 | chr17:7371932 | CHRNB1 | chr17:7348406-7360931:+ | -0.19 | -3.84 | 0.000137 | Height |
| THCA | cis | rs60843830 | 1 | rs55753056 | chr2:243929 | SH3YL1 | chr2:218138-264810:- | -0.93 | -25.94 | 2.93E-93 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs7107174 | 1 | rs55761949 | chr11:77993860 | NARS2 | chr11:78147017-78285909:- | -0.38 | -6.98 | 1.02E-11 | Testicular germ cell tumor |
| THCA | cis | rs73201462 | 1 | rs55762931 | chr3:127847675 | EEFSEC | chr3:127872313-128127488:+ | -0.26 | -4.52 | 7.8E-6 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs934299 | 1 | rs55767108 | chr2:137313594 | THSD7B | chr2:137523115-138435287:+ | 0.22 | 4.08 | 5.39E-5 | Cognitive test performance |
| THCA | cis | rs642803 | 1 | rs557675 | chr11:65566719 | SNX32 | chr11:65601410-65621170:+ | 0.21 | 3.66 | 0.00028 | Urate levels |
| THCA | cis | rs943466 | 1 | rs55775340 | chr6:33751784 | LEMD2 | chr6:33738991-33756906:- | 0.23 | 4.77 | 2.39E-6 | Body mass index |
| THCA | cis | rs9788721 | 1 | rs55781567 | chr15:78857986 | CHRNA5 | chr15:78857906-78886458:+ | -0.44 | -8.5 | 2.4E-16 | Post bronchodilator FEV1;Emphysema imaging phenotypes;Local histogram emphysema pattern;Emphysema distribution in smoking;Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs9475752 | 1 | rs55786720 | chr6:56783647 | BEND6 | chr6:56819773-56892138:+ | -0.31 | -6.73 | 4.73E-11 | Menarche (age at onset) |
| THCA | cis | rs9475752 | 1 | rs55786720 | chr6:56783647 | KIAA1586 | chr6:56911384-56920021:+ | -0.34 | -5.49 | 6.68E-8 | Menarche (age at onset) |
| THCA | cis | rs10849605 | 1 | rs55791720 | chr12:1066834 | ERC1 | chr12:1100404-1605099:+ | 0.09 | 3.45 | 0.000608 | Lung cancer |
| THCA | cis | rs10849605 | 1 | rs55791720 | chr12:1066834 | RAD52 | chr12:1021255-1099219:- | 0.31 | 6.73 | 4.87E-11 | Lung cancer |
| THCA | cis | rs2758886 | 1 | rs55804343 | chr6:39234907 | KCNK16 | chr6:39282475-39290330:- | 0.14 | 3.45 | 0.000612 | Cholesterol, total |